| ncRNA name | SPARC shRNA |
| ncRNA Category | shRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal capillary endothelial cells (HRCECs) |
| Methods | shRNA knockdown, qRT-PCR, CCK-8 assay, transwell assay, Western blot |
| Expression pattern | associated |
| Functional description | SPARC may serve an important role in pathogenesis of diabetic retinopathy. The inhibitory effects on cell viability, migration, angiogenesis and cellular adhesion of HRCECs induced by high concentrations of glucose were reversed once the expression of SPARC was inhibited. |
| PubMed ID | 30651792 |
| Year | 2019 |
| Title | Glucose affects cell viability, migration, angiogenesis and cellular adhesion of human retinal capillary endothelial cells via SPARC. |
| Drug-related ncRNA | NA |
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